John D. Furber
John D. Furber is a scientist and entrepreneur who has been studying the biology of aging, development, and regeneration for more than 25 years. During this time, he has been piecing together a Network Model of the Systems Biology of Human Aging, which can be seen at http://legendarypharma.com/chartbg.html.He is a frequent contributor at meetings in the fields of aging, mitochondria, autophagy, and oxidative stress. These include: Gordon Research Conferences, Cold Spring Harbor Conferences, Ellison Colloquia, Harvard/Glenn Symposia, American Aging Association, Gerontological Society of America, International Society on Aging and Disease, SENS Conferences, Oxygen Club of California World Congresses, and the Bay Area Aging Meetings. From 2000-2011, he served on the Board of Directors of the American Aging Association and was twice elected as VP.
He earned a Bachelor degree in Physics and Mathematics from the University of California at Santa Cruz in 1975, and a Master of Science degree in Biological Sciences (Developmental and Molecular Biology) from the University of California at Irvine in 1990, where he advanced to PhD Candidacy. Between degrees, he served the United States Congress as a Technology Policy Analyst in the Congressional Office of Technology Assessment.
Mr. Furber was a principal in starting five companies during the 1980s and 90s.
Currently, he is running Legendary Pharmaceuticals, small pharmaceutical research company that is engaged in the discovery of pharmaceutical drugs and gene therapies able to repair and reverse accumulating molecular damage to subcellular mitochondria, lysosomes, nuclei, and extracellular proteins in order to prevent and treat serious, late-onset diseases commonly associated with aging. Legendary Pharmaceuticals is a privately-held small business.
Early career: Mr. Furber served four years on Capitol Hill at the Office of Technology Assessment of the United States Congress. In 1979, he joined Solar Electric International, which set up photovoltaic-powered irrigation systems for World Bank projects in developing countries. He also started Pleasant Valley Software Corporation (1984) with a consortium of investors from Europe, India, Canada, and the US.
Laboratory training: In the mid-1980's he changed careers and began graduate school to study the biology of aging and regeneration, first at the University of Kentucky, and then at UC Irvine. During graduate school, his studies emphasized Developmental and Molecular Biology. His early laboratory projects included:
More recent lab work has included work on Lysosomes, Lipofuscin, and Aging at:
- Investigating distribution patterns of developmental pattern-formation signaling molecules during limb regeneration in the African clawed frog, Xenopus laevis.
- Screening the genome of the freshwater hydra for homeobox genes which might be involved in developmental pattern-formation.
- At Genentech, he participated in purification and analysis of the cloned human insulin receptor protein.
- Teaching Biology laboratory courses at the University of Kentucky and the University of California, Irvine.
Currently, at Legendary Pharmaceuticals, he is engaged in pharmacological research involving therapeutic target identification, screening and optimizing candidate therapies, organic synthesis, purification, and testing, as well as ensuring regulatory compliance.
- Visiting Research Scientist at the Buck Institute for Research on Aging.
- Visiting Research Scholar at the University of California, Berkeley QB3
Teaching: During the 1990's, he taught Human Biology at Skyline College, near San Francisco, and taught Management Decision Making at Menlo College, near Stanford. During the 1980's he taught Biology laboratory courses at the University of Kentucky and the University of California. He also started and ran a successful private tutoring service during the 1990's, which helped many students to learn Physics, Mathematics, Statistics, Chemistry, Biology, and Computers. Currently, he frequently lectures on topics related to analyzing the Systems Biology of Aging to find effective therapeutic targets to prevent or treat diseases of aging.
International: Mr. Furber has made multiple trips to Europe, China, India, the Middle East, Southeast Asia, Africa, and the Caribbean to consult, lecture, and study. These have given him an appreciation of other cultures, and advanced possibilities for foreign collaborations.
Professional affiliation: His professional memberships include:
He is a frequent contributor at meetings in the fields of aging, mitochondria, autophagy, and oxidative stress.
He served on the Board of Directors of the American Aging Association from 2000 to 2011, and was Vice President in 2008-2009.
John has created several web pages which provide useful links for researchers and the lay public interested in Aging, Nutrition, Bioinformatics, Genomics, and Molecular Cell Biology. For further details, please see http://www.LegendaryPharma.com/chartbg.html.
The development of consciousness and maturity takes time...
It is grimly ironic that as adults mature
and begin to develop the wisdom
to live their lives well,
the processes of senescence begin to weaken the body and mind,
halting maturation, and eventually causing death.
Just recently, however,
Human intellect has evolved to the point of developing technology
to consciously direct the heretofore randomly-evolved cellular processes
and finally allow realization of the age-old dreams of rejuvenation.
-J.D. Furber 1994
Selected Recent Publications